Current

Article Experimental Implications of a combined perinatal exposure to BPA and BP-3 for offspring folliculogenesis and ovarian function in mice Elisabeth Krieger ab1, Florence Fischer abc1, Julia Howanski ab, Marita Wagner a, Federica Romanelli ab, Beate Fink a, Mario Bauer a, Anne Schumacher abd, Tobias Kretschmer abd2, Ana C. Zenclussen abde2 a Department of Environmental Immunology, Helmholtz-Center for Environmental Research – UFZ, Permoserstrasse 15, Leipzig 04318, Germany b Perinatal Immunology, Saxonian Incubator for Clinical Translation (SIKT), Medical Faculty, Leipzig University, Philipp-Rosenthal-Strasse 55, Leipzig 04103, […]

Małgorzata Starzec-Proserpio, Helena Frawley, Kari Bø, Mélanie Morin Abstract: To evaluate the effectiveness of nonpharmacological conservative therapies for women with CPP. All study data were aggregated, and analyses of the included studies were performed. Effects on pain; sexual measures; psychological and physical function; health-related quality of life; symptom severity/bother; pelvic floor muscle function and morphometry; perceived improvement; and

Nada Rotovnik Kozjek, Gašper Tonin, Michael Gleeson Abstract: The immune system, sports injuries, physical activity and clinical sports nutrition are closely linked. Inadequate nutrition and intense stress in athletes increase the risk of immune dysfunction, injury and disease, while injury reduces the positive effects of physical activity, creating a vicious cycle affecting health and performance. Nutritional support

Martin Pacesa, Oana Pelea, Martin Jinek Abstract: Genome editing has been a transformative force in the life sciences and human medicine, offering unprecedented opportunities to dissect complex biological processes and treat the underlying causes of many genetic diseases. CRISPR-based technologies, with their remarkable efficiency and easy programmability, stand at the forefront of this revolution. In this Review,

Jessica T Y Cheng, Edwin C K Tan, Lifeng Kang Abstract: A significant limitation of the ‘one size fits all’ medication approach is the lack of consideration for special population groups. 3D printing technology has revolutionised the landscape of pharmaceuticals and pharmacy practice, playing an integral role in enabling on-demand production of customised medication. Compared to traditional

Abstract Bovine mastitis remains the main cause of economic losses for dairy farmers. Mammary pathogenic Escherichia coli (MPEC) is related to an acute mastitis and its treatment is still based on the use of antibiotics. In the era of antimicrobial resistance (AMR), bacterial viruses (bacteriophages) present as an efficient treatment or prophylactic option. However, this makes it

Abstract Deceased donor liver transplantation (LT) is a crucial lifesaving option for patients with end-stage liver diseases. Although donation after brain death (DBD) remains the main source of donated organs, exploration of donation after circulatory death (DCD) addresses donor scarcity but introduces challenges due to warm ischemia. While technical advances have improved outcomes, challenges persist,

Abstract Tissue resident memory CD8+ T cells (Trm) are poised for immediate reactivation at sites of pathogen entry and provide optimal protection of mucosal surfaces. The intestinal tract represents a portal of entry for many infectious agents; however, to date specific strategies to enhance Trm responses at this site are lacking. Here, we present TMDI (Transient

Abstract Obesity is a major public health challenge. Glucagon-like peptide-1 receptor agonists (GLP1-RA) and bariatric surgery (BS) are effective weight loss interventions; however, the genetic factors influencing treatment response remain largely unexplored. Moreover, most previous studies have focused on race and ethnicity rather than genetic ancestry. Here we analyzed 10,960 individuals from 9 multiancestry biobank